| 1. Round | 17/01/2021 | Nacional | - | Rentistas | 1:1 |  |
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| 2. Round | 20/01/2021 | Cerro Largo | - | Nacional | 0:0 | ||||
| 3. Round | 31/01/2021 | Nacional | - | Montevideo Wanderers | 2:1 | ||||
| 5. Round | 08/02/2021 | Nacional | - | River Plate | 3:0 | ||||
| 6. Round | 11/02/2021 | Montevideo City Torque | - | Nacional | 1:2 | ||||
| 7. Round | 14/02/2021 | Nacional | - | Plaza Colonia | 1:1 | ||||
| 8. Round | 18/02/2021 | Progreso | - | Nacional | 0:1 | ||||
| 9. Round | 21/02/2021 | Nacional | - | Fénix | 2:2 | ||||
| 10. Round | 27/02/2021 | CA Cerro | - | Nacional | 0:1 | |
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| 13. Round | 22/03/2021 | Nacional | - | Liverpool | 0:4 | |
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| 15. Round | 29/03/2021 | Deportivo Maldonado | - | Nacional | 1:2 |
Uruguay
Italy