| Qual. 2. Round | 16/10/2021 | USGN | - | Al Ahly SC | 1:1 | ||||
| Qual. 2. Round | 23/10/2021 | Al Ahly SC | - | USGN | 6:1 | ||||
| Group A | 18/02/2022 | Al Hilal Omdurman | - | Al Ahly SC | 0:0 | ||||
| Group A | 26/02/2022 | Al Ahly SC | - | Mamelodi Sundowns | 0:1 | ||||
| Group A | 05/03/2022 | Al Ahly SC | - | Al Merrikh SC | 3:2 | ||||
| Group A | 12/03/2022 | Mamelodi Sundowns | - | Al Ahly SC | 1:0 | ||||
| Group A | 18/03/2022 | Al Merrikh SC | - | Al Ahly SC | 1:3 | ||||
| Group A | 03/04/2022 | Al Ahly SC | - | Al Hilal Omdurman | 1:0 | ||||
| Quarter-finals | 16/04/2022 | Al Ahly SC | - | Raja Casablanca | 2:1 |  |
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| Quarter-finals | 22/04/2022 | Raja Casablanca | - | Al Ahly SC | 1:1 | ||||
| Semi-finals | 07/05/2022 | Al Ahly SC | - | ES Sétif | 4:0 | ||||
| Semi-finals | 14/05/2022 | ES Sétif | - | Al Ahly SC | 2:2 | ||||
| Final | 30/05/2022 | Wydad AC | - | Al Ahly SC | 2:0 | |
Mali