| Group F | 14/09/2021 | BSC Young Boys [Youth] | - | Manchester United [Youth] | 0:1 | ||||
| Group F | 29/09/2021 | Manchester United [Youth] | - | Villarreal CF [Youth] | 1:4 |  |
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| Group F | 20/10/2021 | Manchester United [Youth] | - | Atalanta [Youth] | 4:2 | ||||
| Group F | 02/11/2021 | Atalanta [Youth] | - | Manchester United [Youth] | 1:2 | |
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| Group F | 23/11/2021 | Villarreal CF [Youth] | - | Manchester United [Youth] | 1:2 | |
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| Round of 16 | 01/03/2022 | Manchester United [Youth] | - | Borussia Dortmund [Youth] | 1:3 pso |
Spain