| 2. Round | 15/01/2022 | Atlas Guadalajara | - | Atlético San Luis | 1:0 | ||||
| 1. Round | 20/01/2022 | Club León | - | Atlas Guadalajara | 1:1 | ||||
| 3. Round | 23/01/2022 | CF América | - | Atlas Guadalajara | 0:2 | ||||
| 4. Round | 07/02/2022 | Atlas Guadalajara | - | Santos Laguna | 2:1 | ||||
| 5. Round | 12/02/2022 | Puebla FC | - | Atlas Guadalajara | 1:1 | ||||
| 6. Round | 21/02/2022 | Atlas Guadalajara | - | Pumas UNAM | 0:0 | ||||
| 7. Round | 26/02/2022 | Club Tijuana | - | Atlas Guadalajara | 2:0 |  |
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| 9. Round | 05/03/2022 | Gallos Blancos | - | Atlas Guadalajara | 0:3 dec. |  |
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| 10. Round | 12/03/2022 | FC Juárez | - | Atlas Guadalajara | 1:2 | ||||
| 11. Round | 21/03/2022 | Atlas Guadalajara | - | Deportivo Guadalajara | 1:1 | ||||
| 12. Round | 03/04/2022 | Cruz Azul | - | Atlas Guadalajara | 1:0 | ||||
| 13. Round | 08/04/2022 | Atlas Guadalajara | - | Club Necaxa | 2:1 | ||||
| 14. Round | 15/04/2022 | Atlas Guadalajara | - | Mazatlán FC | 1:2 | |
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| 15. Round | 21/04/2022 | CF Monterrey | - | Atlas Guadalajara | 0:0 | ||||
| 16. Round | 24/04/2022 | Deportivo Toluca | - | Atlas Guadalajara | 2:4 | |
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| 17. Round | 01/05/2022 | Atlas Guadalajara | - | UANL Tigres | 1:1 |
Peru