| 3. Round | 03/08/2021 | UANL Tigres [Women] | - | Club Necaxa [Women] | 8:1 | ||||
| 4. Round | 09/08/2021 | Club Necaxa [Women] | - | Santos Laguna [Women] | 0:3 | ||||
| 6. Round | 23/08/2021 | Club Necaxa [Women] | - | Puebla FC [Women] | 1:0 | ||||
| 9. Round | 13/09/2021 | Club Necaxa [Women] | - | Mazatlán FC [Women] | 3:0 | ||||
| 12. Round | 09/10/2021 | Atlas Guadalajara [Women] | - | Club Necaxa [Women] | 1:0 | ||||
| 13. Round | 18/10/2021 | Club Necaxa [Women] | - | CF Monterrey [Women] | 1:6 | ||||
| 16. Round | 13/11/2021 | Club Necaxa [Women] | - | FC Juárez [Women] | 3:1 |
Mexico