| 1. Round | 28/08/2021 | ACF Fiorentina [Youth] | - | Juventus [Youth] | 1:2 | ||||
| 5. Round | 17/10/2021 | Hellas Verona [Youth] | - | ACF Fiorentina [Youth] | 0:3 | ||||
| 9. Round | 20/11/2021 | Empoli FC [Youth] | - | ACF Fiorentina [Youth] | 2:0 | ||||
| 10. Round | 28/11/2021 | ACF Fiorentina [Youth] | - | Genoa CFC [Youth] | 0:0 | ||||
| 11. Round | 05/12/2021 | US Lecce [Youth] | - | ACF Fiorentina [Youth] | 0:0 | ||||
| 13. Round | 09/02/2022 | SPAL 2013 Ferrara [Youth] | - | ACF Fiorentina [Youth] | 0:2 | ||||
| 18. Round | 12/02/2022 | Juventus [Youth] | - | ACF Fiorentina [Youth] | 4:0 | ||||
| 19. Round | 16/02/2022 | ACF Fiorentina [Youth] | - | Inter [Youth] | 3:1 |  |
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| 25. Round | 19/03/2022 | Atalanta [Youth] | - | ACF Fiorentina [Youth] | 2:0 | ||||
| 33. Round | 09/05/2022 | ACF Fiorentina [Youth] | - | Sampdoria [Youth] | 1:2 | ||||
| 34. Round | 15/05/2022 | AS Roma [Youth] | - | ACF Fiorentina [Youth] | 4:1 |
Italy