| 5. Round | 15/08/2021 | Dinamo Bryansk | - | FK Sakhalin | 2:0 |  |
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| 6. Round | 21/08/2021 | FK Kaluga | - | FK Sakhalin | 1:1 | ||||
| 7. Round | 02/09/2021 | FK Sakhalin | - | Zenit Penza | 0:1 | ||||
| 8. Round | 05/09/2021 | FK Sakhalin | - | Sokol Saratov | 0:1 | ||||
| 9. Round | 11/09/2021 | Salyut Belgorod | - | FK Sakhalin | 0:2 | ||||
| 10. Round | 14/09/2021 | Avangard Kursk | - | FK Sakhalin | 2:0 | |
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| 12. Round | 26/09/2021 | FK Sakhalin | - | Dinamo Vladivostok | 1:5 | ||||
| 18. Round | 22/10/2021 | FK Sakhalin | - | FK Kaluga | 0:1 | ||||
| 22. Round | 14/11/2021 | FK Sakhalin | - | Avangard Kursk | 0:3 |
Russia