| Group F | 30/09/2021 | PAOK Saloniki | - | Slovan Bratislava | 1:1 | ||||
| Group F | 21/10/2021 | FC København | - | PAOK Saloniki | 1:2 |  |
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| Group F | 04/11/2021 | PAOK Saloniki | - | FC København | 1:2 | |
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| Group F | 25/11/2021 | Slovan Bratislava | - | PAOK Saloniki | 0:0 | ||||
| Group F | 09/12/2021 | PAOK Saloniki | - | Lincoln Red Imps | 2:0 | |
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| Play-offs | 17/02/2022 | FC Midtjylland | - | PAOK Saloniki | 1:0 | ||||
| Play-offs | 24/02/2022 | PAOK Saloniki | - | FC Midtjylland | 5:3 pso | |
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| Round of 16 | 10/03/2022 | PAOK Saloniki | - | KAA Gent | 1:0 | |
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| Quarter-finals | 07/04/2022 | Olympique Marseille | - | PAOK Saloniki | 2:1 | ||||
| Quarter-finals | 14/04/2022 | PAOK Saloniki | - | Olympique Marseille | 0:1 |
Serbia