| Quarter-finals | 18/04/2021 | Gavilanes de Matamoros | - | Cruz Azul Hidalgo | 0:0 | ||||
| Quarter-finals | 24/04/2021 | Cruz Azul Hidalgo | - | Gavilanes de Matamoros | 1:0 | ||||
| Semi-finals | 30/04/2021 | Alacranes de Durango | - | Cruz Azul Hidalgo | 1:1 | ||||
| Semi-finals | 02/05/2021 | Cruz Azul Hidalgo | - | Alacranes de Durango | 1:1 | ||||
| Final | 10/05/2021 | Club Irapuato | - | Cruz Azul Hidalgo | 2:0 | ||||
| Final | 16/05/2021 | Cruz Azul Hidalgo | - | Club Irapuato | 1:1 |
Panama