1st(1st leg) Club Irapuato - Inter Playa 0:0
2nd (2nd leg) Inter Playa - Club Irapuato 1:2
1st(1st leg): 30/04/2021 02:00 2nd (2nd leg): 02/05/2021 22:00 Winner: Club Irapuato
1st(1st leg) Alacranes de Durango - Cruz Azul Hidalgo 1:1
2nd (2nd leg) Cruz Azul Hidalgo - Alacranes de Durango 1:1
1st(1st leg): 30/04/2021 02:30 2nd (2nd leg): 02/05/2021 22:00