| 1. Round | 12/08/2005 | Fortuna Sittard | - | Go Ahead Eagles | 3:2 |  |
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| 3. Round | 22/08/2005 | Fortuna Sittard | - | VVV-Venlo | 0:2 | |
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| 4. Round | 26/08/2005 | AGOVV | - | Fortuna Sittard | 3:0 | ||||
| 5. Round | 29/08/2005 | SC Cambuur | - | Fortuna Sittard | 2:2 | |
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| 12. Round | 07/10/2005 | Fortuna Sittard | - | FC Volendam | 0:1 | ||||
| 13. Round | 14/10/2005 | TOP Oss | - | Fortuna Sittard | 3:1 | ||||
| 18. Round | 18/11/2005 | Fortuna Sittard | - | FC Den Bosch | 1:2 | ||||
| 21. Round | 02/12/2005 | Fortuna Sittard | - | AGOVV | 2:3 | ||||
| 19. Round | 06/12/2005 | SBV Excelsior | - | Fortuna Sittard | 3:0 | ||||
| 25. Round | 13/01/2006 | FC Emmen | - | Fortuna Sittard | 2:1 | ||||
| 28. Round | 06/02/2006 | Fortuna Sittard | - | TOP Oss | 2:1 | ||||
| 29. Round | 10/02/2006 | FC Zwolle | - | Fortuna Sittard | 3:0 | ||||
| 30. Round | 17/02/2006 | Fortuna Sittard | - | HFC Haarlem | 0:3 | ||||
| 31. Round | 20/02/2006 | MVV | - | Fortuna Sittard | 3:1 | |
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| 33. Round | 10/03/2006 | FC Volendam | - | Fortuna Sittard | 2:0 | ||||
| 34. Round | 13/03/2006 | Fortuna Sittard | - | FC Dordrecht | 0:3 | ||||
| 35. Round | 17/03/2006 | BV Veendam | - | Fortuna Sittard | 2:2 | |
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| 36. Round | 24/03/2006 | Fortuna Sittard | - | FC Eindhoven | 1:2 |
Belgium