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| 10/02/2006 | 19:00 | HFC Haarlem | - | VVV-Venlo | 2:0 (1:0) | |
| 19:00 | FC Zwolle | - | Fortuna Sittard | 3:0 (0:0) | ||
| 19:00 | TOP Oss | - | SC Cambuur | 1:0 (1:0) | ||
| 19:00 | MVV | - | Stormvogels Telstar | 3:4 (2:1) | ||
| 19:00 | Helmond Sport | - | AGOVV | 1:2 (1:0) | ||
| 19:00 | BV Veendam | - | FC Eindhoven | 2:1 (2:1) | ||
| 19:00 | FC Dordrecht | - | FC Den Bosch | 2:2 (0:1) | ||
| 19:00 | FC Omniworld | - | FC Emmen | 3:4 (2:1) | ||
| 19:00 | FC Volendam | - | SBV Excelsior | 0:0 (0:0) | ||
| 12/02/2006 | 13:30 | De Graafschap | - | Go Ahead Eagles | 2:2 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 29 | 17 | 7 | 5 | 57:18 | 39 | 58 |
| 2 |
|
VVV-Venlo | 29 | 16 | 7 | 6 | 40:17 | 23 | 55 |
| 3 |
|
FC Emmen | 29 | 16 | 5 | 8 | 57:36 | 21 | 53 |
| 4 |
|
FC Volendam | 29 | 14 | 8 | 7 | 41:30 | 11 | 50 |
| 5 |
|
FC Den Bosch | 29 | 13 | 10 | 6 | 52:40 | 12 | 49 |
| 6 |
|
HFC Haarlem | 29 | 13 | 6 | 10 | 48:46 | 2 | 45 |
| 7 |
|
Helmond Sport | 29 | 13 | 6 | 10 | 45:45 | 0 | 45 |
| 8 |
|
FC Zwolle | 29 | 12 | 8 | 9 | 48:39 | 9 | 44 |
| 9 |
|
De Graafschap | 29 | 12 | 7 | 10 | 43:38 | 5 | 43 |
| 10 |
|
MVV | 29 | 10 | 10 | 9 | 42:39 | 3 | 40 |
| 11 |
|
BV Veendam | 29 | 11 | 7 | 11 | 43:43 | 0 | 40 |
| 12 |
|
AGOVV | 29 | 12 | 4 | 13 | 49:50 | -1 | 40 |
| 13 |
|
FC Dordrecht | 29 | 9 | 10 | 10 | 36:35 | 1 | 37 |
| 14 |
|
TOP Oss | 29 | 9 | 10 | 10 | 35:43 | -8 | 37 |
| 15 |
|
Stormvogels Telstar | 29 | 7 | 10 | 12 | 29:45 | -16 | 31 |
| 16 |
|
Go Ahead Eagles | 29 | 6 | 11 | 12 | 34:52 | -18 | 29 |
| 17 |
|
SC Cambuur | 29 | 7 | 10 | 12 | 30:41 | -11 | 28 |
| 18 |
|
FC Omniworld | 29 | 7 | 6 | 16 | 39:62 | -23 | 27 |
| 19 |
|
FC Eindhoven | 29 | 6 | 5 | 18 | 37:51 | -14 | 23 |
| 20 |
|
Fortuna Sittard | 29 | 2 | 9 | 18 | 28:63 | -35 | 15 |
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