| 2. Round | 18/08/2021 | Etoile Carouge FC | - | SC Cham | 0:0 | ||||
| 3. Round | 21/08/2021 | SC Cham | - | FC Zürich II | 3:0 | ||||
| 4. Round | 28/08/2021 | FC Breitenrain Bern | - | SC Cham | 1:1 | ||||
| 5. Round | 04/09/2021 | SC Cham | - | SC Brühl | 0:1 | ||||
| 14. Round | 06/11/2021 | SC Cham | - | FC Biel/Bienne | 2:2 | ||||
| 15. Round | 13/11/2021 | FC Basel 1893 II | - | SC Cham | 3:4 | ||||
| 16. Round | 20/11/2021 | FC Sion II | - | SC Cham | 3:4 | ||||
| 17. Round | 27/11/2021 | SC Cham | - | Etoile Carouge FC | 1:0 | ||||
| 19. Round | 19/02/2022 | SC Cham | - | FC Breitenrain Bern | 0:0 | ||||
| 20. Round | 26/02/2022 | SC Brühl | - | SC Cham | 2:2 | ||||
| 21. Round | 05/03/2022 | SC Cham | - | SC YF/Juventus Zürich | 1:0 | ||||
| 22. Round | 12/03/2022 | FC Rapperswil-Jona | - | SC Cham | 1:1 | ||||
| 23. Round | 19/03/2022 | FC Black Stars Basel | - | SC Cham | 0:2 | ||||
| 24. Round | 26/03/2022 | SC Cham | - | FC Bavois | 1:1 | ||||
| 25. Round | 02/04/2022 | FC Stade Nyonnais | - | SC Cham | 3:3 | ||||
| 26. Round | 06/04/2022 | SC Cham | - | AC Bellinzona | 1:1 | ||||
| 28. Round | 16/04/2022 | SC Cham | - | FC Chiasso | 2:4 | ||||
| 29. Round | 23/04/2022 | FC Biel/Bienne | - | SC Cham | 3:4 | ||||
| 30. Round | 30/04/2022 | SC Cham | - | FC Basel 1893 II | 2:3 |  |
Switzerland