| 1. Round | 06/08/2022 | FC Hradec Králové [Youth] | - | FK Mladá Boleslav [Youth] | 0:1 | ||||
| 2. Round | 13/08/2022 | Viktoria Plzeň [Youth] | - | FC Hradec Králové [Youth] | 4:1 | ||||
| 3. Round | 19/08/2022 | FC Hradec Králové [Youth] | - | FC Zbrojovka Brno [Youth] | 2:3 | ||||
| 4. Round | 27/08/2022 | Slavia Praha [Youth] | - | FC Hradec Králové [Youth] | 4:0 | ||||
| 8. Round | 30/08/2022 | FC Zlín [Youth] | - | FC Hradec Králové [Youth] | 5:1 | ||||
| 5. Round | 03/09/2022 | FC Hradec Králové [Youth] | - | FK Dukla Praha [Youth] | 3:1 | ||||
| 6. Round | 10/09/2022 | MFK Karviná [Youth] | - | FC Hradec Králové [Youth] | 2:2 | ||||
| 7. Round | 17/09/2022 | FC Hradec Králové [Youth] | - | FK Příbram [Youth] | 1:1 | ||||
| 9. Round | 01/10/2022 | FC Hradec Králové [Youth] | - | AC Sparta Praha [Youth] | 2:1 | ||||
| 10. Round | 08/10/2022 | FC Hradec Králové [Youth] | - | Vysočina Jihlava [Youth] | 0:1 | ||||
| 11. Round | 14/10/2022 | FK Pardubice [Youth] | - | FC Hradec Králové [Youth] | 2:0 | ||||
| 12. Round | 22/10/2022 | FC Hradec Králové [Youth] | - | Banik Ostrava [Youth] | 3:1 |
Czech Republic