| 1. Round | 10/01/2022 | Deportivo Guadalajara | - | Mazatlán FC | 3:0 | ||||
| 2. Round | 16/01/2022 | CF Pachuca | - | Deportivo Guadalajara | 2:1 | ||||
| 4. Round | 10/02/2022 | FC Juárez | - | Deportivo Guadalajara | 1:3 | ||||
| 5. Round | 12/02/2022 | Deportivo Guadalajara | - | UANL Tigres | 1:3 | ||||
| 9. Round | 06/03/2022 | Deportivo Guadalajara | - | Santos Laguna | 1:0 | ||||
| 10. Round | 13/03/2022 | Deportivo Guadalajara | - | CF América | 0:0 |  |
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| 11. Round | 21/03/2022 | Atlas Guadalajara | - | Deportivo Guadalajara | 1:1 | |
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| 12. Round | 14/04/2022 | Deportivo Guadalajara | - | CF Monterrey | 1:3 | |
Mexico