| 1. Round | 07/11/2021 | Veria FC | - | Almopos Arideas | 1:0 |  |
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| 2. Round | 14/11/2021 | Almopos Arideas | - | Apollon Pontou | 2:0 | ||||
| 3. Round | 21/11/2021 | Anagennisi Karditsa | - | Almopos Arideas | 4:0 | ||||
| 4. Round | 24/11/2021 | Almopos Arideas | - | Pierikos Katerini | 3:1 | ||||
| 5. Round | 28/11/2021 | Xanthi FC | - | Almopos Arideas | 2:0 | ||||
| 7. Round | 11/12/2021 | AO Kavala | - | Almopos Arideas | 0:6 | ||||
| 10. Round | 29/12/2021 | Olympiakos Volou | - | Almopos Arideas | 1:1 | ||||
| 13. Round | 12/01/2022 | Almopos Arideas | - | AE Lárissa | 0:1 | ||||
| 16. Round | 30/01/2022 | Panserraikos | - | Almopos Arideas | 1:3 | ||||
| 18. Round | 12/02/2022 | Almopos Arideas | - | Veria FC | 1:2 | ||||
| 19. Round | 16/02/2022 | Apollon Pontou | - | Almopos Arideas | 1:1 | ||||
| 20. Round | 20/02/2022 | Almopos Arideas | - | Anagennisi Karditsa | 1:0 | ||||
| 33. Round | 27/04/2022 | Almopos Arideas | - | Panserraikos | 0:1 |
Greece