 |
 |
|
|
| 12/01/2022 | 13:00 | Thesprotos | - | Olympiakos Piraeus II | 2:1 (1:1) | |
| 13:00 | AO Kavala | - | Apollon Lárissa | 0:0 (0:0) | ||
| 13:00 | Almopos Arideas | - | AE Lárissa | 0:1 (0:1) | ||
| 13/01/2022 | 13:00 | Niki Volou FC | - | AO Trikala | 3:0 (1:0) | |
| 02/02/2022 | 13:00 | Pierikos Katerini | - | AEP Iraklis FC | 2:2 (0:2) | |
| 09/02/2022 | 13:30 | Xanthi FC | - | Panserraikos | 0:0 (0:0) | |
| 02/03/2022 | 13:00 | Olympiakos Volou | - | PAOK Saloniki II | 3:1 (3:1) | |
| 13:30 | Anagennisi Karditsa | - | Veria FC | 5:2 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Anagennisi Karditsa | 13 | 8 | 2 | 3 | 24:11 | 13 | 26 |
| 2 |
|
Xanthi FC | 12 | 7 | 4 | 1 | 20:6 | 14 | 25 |
| 3 |
|
Veria FC | 12 | 7 | 3 | 2 | 26:12 | 14 | 24 |
| 4 |
|
AE Lárissa | 12 | 6 | 5 | 1 | 17:4 | 13 | 23 |
| 5 |
|
Niki Volou FC | 12 | 5 | 5 | 2 | 19:7 | 12 | 20 |
| 6 |
|
Olympiakos Piraeus II | 12 | 4 | 6 | 2 | 13:10 | 3 | 18 |
| 7 |
|
Thesprotos | 12 | 5 | 2 | 5 | 16:9 | 7 | 17 |
| 8 |
|
AO Trikala | 13 | 4 | 4 | 5 | 12:19 | -7 | 16 |
| 9 |
|
AEP Iraklis FC | 12 | 2 | 9 | 1 | 8:8 | 0 | 15 |
| 10 |
|
PAOK Saloniki II | 13 | 3 | 6 | 4 | 15:16 | -1 | 15 |
| 11 |
|
Almopos Arideas | 12 | 4 | 2 | 6 | 14:13 | 1 | 14 |
| 12 |
|
Pierikos Katerini | 13 | 2 | 6 | 5 | 14:14 | 0 | 12 |
| 13 |
|
Apollon Pontou | 12 | 3 | 3 | 6 | 17:21 | -4 | 12 |
| 14 |
|
Olympiakos Volou | 12 | 3 | 3 | 6 | 15:19 | -4 | 12 |
| 15 |
|
Panserraikos | 12 | 2 | 5 | 5 | 11:17 | -6 | 11 |
| 16 |
|
Apollon Lárissa | 12 | 1 | 5 | 6 | 8:18 | -10 | 8 |
| 17 |
|
AO Kavala | 12 | 2 | 2 | 8 | 5:50 | -45 | 8 |
| Playoffs | |
| Relegation |
