| 2. Round | 17/01/2021 | Gallos Blancos [U20] | - | Atlas Guadalajara [U20] | 3:0 | ||||
| 3. Round | 23/01/2021 | Atlas Guadalajara [U20] | - | UANL Tigres [U20] | 0:0 | ||||
| 7. Round | 20/02/2021 | Atlas Guadalajara [U20] | - | CF América [U20] | 2:1 | ||||
| 8. Round | 27/02/2021 | Deportivo Toluca [U20] | - | Atlas Guadalajara [U20] | 0:1 | ||||
| 9. Round | 02/03/2021 | Atlas Guadalajara [U20] | - | Atlético San Luis [U20] | 2:0 | ||||
| 11. Round | 12/03/2021 | Puebla FC [U20] | - | Atlas Guadalajara [U20] | 0:5 | ||||
| 12. Round | 20/03/2021 | Cruz Azul [U20] | - | Atlas Guadalajara [U20] | 0:4 | ||||
| 13. Round | 03/04/2021 | Atlas Guadalajara [U20] | - | Club Tijuana [U20] | 0:1 | ||||
| 15. Round | 16/04/2021 | Mazatlán FC [U20] | - | Atlas Guadalajara [U20] | 2:2 | ||||
| 16. Round | 24/04/2021 | Atlas Guadalajara [U20] | - | Deportivo Guadalajara [U20] | 3:2 |  |
Mexico