| 1. Round | 15/08/2021 | Lommel SK | - | Waasland-Beveren | 2:3 |  |
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| 2. Round | 21/08/2021 | Royal Excel Mouscron | - | Lommel SK | 0:1 | ||||
| 4. Round | 11/09/2021 | Excelsior Virton | - | Lommel SK | 2:1 | ||||
| 5. Round | 19/09/2021 | Lommel SK | - | Lierse Kempenzonen | 3:1 |  |
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| 6. Round | 25/09/2021 | RWD Molenbeek | - | Lommel SK | 1:2 | |
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| 7. Round | 01/10/2021 | KVC Westerlo | - | Lommel SK | 2:0 | ||||
| 8. Round | 17/10/2021 | Lommel SK | - | Royal Excel Mouscron | 3:0 | |
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| 9. Round | 24/10/2021 | Waasland-Beveren | - | Lommel SK | 2:1 | |
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| 10. Round | 31/10/2021 | Lommel SK | - | RWD Molenbeek | 2:3 | ||||
| 11. Round | 05/11/2021 | Lommel SK | - | Excelsior Virton | 1:3 | ||||
| 12. Round | 21/11/2021 | KMSK Deinze | - | Lommel SK | 3:3 | ||||
| 13. Round | 27/11/2021 | Lommel SK | - | KVC Westerlo | 0:1 | |
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| 14. Round | 05/12/2021 | Lierse Kempenzonen | - | Lommel SK | 2:2 | ||||
| 15. Round | 11/12/2021 | Royal Excel Mouscron | - | Lommel SK | 2:1 | |
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| 16. Round | 17/12/2021 | Lommel SK | - | Waasland-Beveren | 1:1 | |
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