| 2. Round | 23/07/2021 | Fakel Voronezh 2 | - | FK Sakhalin | 0:2 | ||||
| 4. Round | 08/08/2021 | Arsenal Tula 2 | - | FK Sakhalin | 3:0 |  |
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| 6. Round | 21/08/2021 | FK Kaluga | - | FK Sakhalin | 1:1 | ||||
| 8. Round | 05/09/2021 | FK Sakhalin | - | Sokol Saratov | 0:1 | ||||
| 9. Round | 11/09/2021 | Salyut Belgorod | - | FK Sakhalin | 0:2 | ||||
| 10. Round | 14/09/2021 | Avangard Kursk | - | FK Sakhalin | 2:0 | ||||
| 12. Round | 26/09/2021 | FK Sakhalin | - | Dinamo Vladivostok | 1:5 | ||||
| 14. Round | 03/10/2021 | FK Sakhalin | - | Fakel Voronezh 2 | 1:0 | ||||
| 15. Round | 10/10/2021 | FK Sakhalin | - | FK Ryazan | 0:2 | ||||
| 16. Round | 13/10/2021 | FK Sakhalin | - | Arsenal Tula 2 | 3:2 | |
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| 17. Round | 19/10/2021 | FK Sakhalin | - | Dinamo Bryansk | 1:1 | |
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| 18. Round | 22/10/2021 | FK Sakhalin | - | FK Kaluga | 0:1 | ||||
| 19. Round | 31/10/2021 | Zenit Penza | - | FK Sakhalin | 3:0 | ||||
| 20. Round | 03/11/2021 | Sokol Saratov | - | FK Sakhalin | 3:0 | ||||
| 11. Round | 07/11/2021 | Dinamo Vladivostok | - | FK Sakhalin | 4:0 | ||||
| 21. Round | 11/11/2021 | FK Sakhalin | - | Salyut Belgorod | 0:1 | ||||
| 22. Round | 14/11/2021 | FK Sakhalin | - | Avangard Kursk | 0:3 |
Russia