| 1. Round | 11/01/2022 | Pumas UNAM | - | Deportivo Toluca | 5:0 |  |
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| 2. Round | 15/01/2022 | Gallos Blancos | - | Pumas UNAM | 1:3 | ||||
| 3. Round | 23/01/2022 | Pumas UNAM | - | UANL Tigres | 1:2 | ||||
| 4. Round | 06/02/2022 | Club Tijuana | - | Pumas UNAM | 1:0 | |
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| 5. Round | 13/02/2022 | Pumas UNAM | - | Club León | 2:1 |  |
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| 6. Round | 21/02/2022 | Atlas Guadalajara | - | Pumas UNAM | 0:0 | ||||
| 7. Round | 27/02/2022 | Pumas UNAM | - | CF América | 0:0 | ||||
| 8. Round | 03/03/2022 | Santos Laguna | - | Pumas UNAM | 3:2 | |
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| 10. Round | 13/03/2022 | Cruz Azul | - | Pumas UNAM | 2:1 | ||||
| 11. Round | 19/03/2022 | Pumas UNAM | - | Club Necaxa | 1:3 | ||||
| 9. Round | 26/03/2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 12. Round | 03/04/2022 | FC Juárez | - | Pumas UNAM | 0:1 | ||||
| 13. Round | 09/04/2022 | Puebla FC | - | Pumas UNAM | 2:2 | |
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| 14. Round | 17/04/2022 | Pumas UNAM | - | CF Monterrey | 2:0 | ||||
| 15. Round | 21/04/2022 | Atlético San Luis | - | Pumas UNAM | 2:0 | ||||
| 16. Round | 24/04/2022 | Deportivo Guadalajara | - | Pumas UNAM | 3:1 | ||||
| 17. Round | 01/05/2022 | Pumas UNAM | - | CF Pachuca | 2:0 |
Mexico