| 5. Round | 28/07/2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
| 6. Round | 31/07/2022 | Pumas UNAM | - | CF Monterrey | 1:1 | ||||
| 8. Round | 14/08/2022 | Pumas UNAM | - | CF América | 0:3 | ||||
| 12. Round | 04/09/2022 | Atlas Guadalajara | - | Pumas UNAM | 0:0 |  |
|||
| 13. Round | 08/09/2022 | Pumas UNAM | - | Gallos Blancos | 4:1 | ||||
| 14. Round | 11/09/2022 | Deportivo Toluca | - | Pumas UNAM | 2:2 | |
|||
| 15. Round | 18/09/2022 | Pumas UNAM | - | Cruz Azul | 1:2 | ||||
| 7. Round | 24/09/2022 | Puebla FC | - | Pumas UNAM | 2:1 | |
|||
| 17. Round | 01/10/2022 | FC Juárez | - | Pumas UNAM | 3:1 |
Mexico