| 2. Round | 27/07/2021 | Club León [Women] | - | UANL Tigres [Women] | 0:2 | ||||
| 4. Round | 07/08/2021 | Atlas Guadalajara [Women] | - | UANL Tigres [Women] | 0:4 | ||||
| 6. Round | 21/08/2021 | Cruz Azul [Women] | - | UANL Tigres [Women] | 0:3 | ||||
| 8. Round | 03/09/2021 | Gallos Blancos [Women] | - | UANL Tigres [Women] | 1:2 | ||||
| 9. Round | 13/09/2021 | UANL Tigres [Women] | - | CF Pachuca [Women] | 5:0 | ||||
| 10. Round | 28/09/2021 | UANL Tigres [Women] | - | Club Tijuana [Women] | 3:0 | ||||
| 12. Round | 10/10/2021 | UANL Tigres [Women] | - | CF Monterrey [Women] | 2:1 | ||||
| 15. Round | 09/11/2021 | UANL Tigres [Women] | - | Pumas UNAM [Women] | 2:1 | ||||
| 16. Round | 14/11/2021 | CF América [Women] | - | UANL Tigres [Women] | 1:1 | ||||
| 17. Round | 22/11/2021 | Santos Laguna [Women] | - | UANL Tigres [Women] | 0:2 |
Mexico