| 4. Round | 19/09/2020 | Pau FC | - | EA Guingamp | 0:1 | ||||
| 5. Round | 26/09/2020 | EA Guingamp | - | Grenoble Foot 38 | 1:0 | ||||
| 7. Round | 19/10/2020 | EA Guingamp | - | AJ Auxerre | 2:0 | ||||
| 8. Round | 24/10/2020 | SM Caen | - | EA Guingamp | 1:0 |  |
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| 9. Round | 31/10/2020 | EA Guingamp | - | FC Sochaux | 0:0 | ||||
| 10. Round | 07/11/2020 | Clermont Foot 63 | - | EA Guingamp | 0:0 | |
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| 11. Round | 23/11/2020 | EA Guingamp | - | AC Ajaccio | 2:2 | ||||
| 12. Round | 28/11/2020 | Rodez AF | - | EA Guingamp | 1:1 | ||||
| 13. Round | 01/12/2020 | EA Guingamp | - | ESTAC Troyes | 1:2 | ||||
| 14. Round | 05/12/2020 | Toulouse FC | - | EA Guingamp | 2:2 | ||||
| 16. Round | 18/12/2020 | FC Chambly | - | EA Guingamp | 3:0 | ||||
| 17. Round | 22/12/2020 | Paris FC | - | EA Guingamp | 3:2 | ||||
| 18. Round | 05/01/2021 | EA Guingamp | - | Amiens SC | 2:2 | ||||
| 19. Round | 08/01/2021 | LB Châteauroux | - | EA Guingamp | 2:3 | |
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| 20. Round | 16/01/2021 | EA Guingamp | - | AS Nancy Lorraine | 0:0 | ||||
| 21. Round | 23/01/2021 | Havre AC | - | EA Guingamp | 1:1 | ||||
| 22. Round | 30/01/2021 | EA Guingamp | - | Pau FC | 2:3 |  |
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| 24. Round | 05/02/2021 | EA Guingamp | - | USL Dunkerque | 0:0 | ||||
| 25. Round | 13/02/2021 | AJ Auxerre | - | EA Guingamp | 1:1 |
France