| Group 2 | 16/02/2005 | Bolívar | - | Santos FC | 4:3 | ||||
| Group 2 | 03/03/2005 | Santos FC | - | Danubio | 3:2 |  |
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| Group 2 | 17/03/2005 | LDU Quito | - | Santos FC | 2:1 | ||||
| Group 2 | 21/04/2005 | Danubio | - | Santos FC | 1:2 | ||||
| Group 2 | 11/05/2005 | Santos FC | - | Bolívar | 6:0 |  |
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| Round of 16 | 20/05/2005 | Universidad de Chile | - | Santos FC | 2:1 | ||||
| Round of 16 | 25/05/2005 | Santos FC | - | Universidad de Chile | 3:0 | ||||
| Quarter-finals | 01/06/2005 | Athletico Paranaense | - | Santos FC | 3:2 | ||||
| Quarter-finals | 16/06/2005 | Santos FC | - | Athletico Paranaense | 0:2 |
Brazil