| 2. Round | 27/03/2022 | Cobreloa | - | Deportes Iquique | 2:0 | ||||
| 3. Round | 19/06/2022 | Cobreloa | - | Palestino | 0:1 | ||||
| 3. Round | 26/06/2022 | Palestino | - | Cobreloa | 6:7 pso |  |
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| Round of 16 | 16/08/2022 | Santiago Morning | - | Cobreloa | 0:0 | ||||
| Round of 16 | 20/08/2022 | Cobreloa | - | Santiago Morning | 1:0 | ||||
| Quarter-finals | 23/09/2022 | CD Magallanes | - | Cobreloa | 0:0 | |
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| Quarter-finals | 29/09/2022 | Cobreloa | - | CD Magallanes | 2:4 pso |
Chile