| 1. Round | 06/08/2022 | 1. FSV Mainz 05 II | - | SSV Ulm 1846 | 0:4 |  |
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| 2. Round | 13/08/2022 | TSV Steinbach Haiger | - | 1. FSV Mainz 05 II | 0:1 | ||||
| 3. Round | 20/08/2022 | SG Barockstadt Fulda-Lehnerz | - | 1. FSV Mainz 05 II | 1:3 | ||||
| 5. Round | 04/09/2022 | Eintracht Trier | - | 1. FSV Mainz 05 II | 0:2 | ||||
| 6. Round | 10/09/2022 | 1. FSV Mainz 05 II | - | Wormatia Worms | 2:3 | ||||
| 7. Round | 13/09/2022 | 1899 Hoffenheim II | - | 1. FSV Mainz 05 II | 1:3 |  |
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| 8. Round | 17/09/2022 | 1. FSV Mainz 05 II | - | Rot-Weiß Koblenz | 4:1 | |
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| 10. Round | 02/10/2022 | 1. FSV Mainz 05 II | - | SGV Freiberg | 1:2 | ||||
| 9. Round | 05/10/2022 | FSV Frankfurt | - | 1. FSV Mainz 05 II | 2:1 | ||||
| 11. Round | 09/10/2022 | VfR Aalen | - | 1. FSV Mainz 05 II | 0:2 | |
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| 14. Round | 30/10/2022 | 1. FSV Mainz 05 II | - | Hessen Kassel | 3:1 | |
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| 15. Round | 05/11/2022 | Kickers Offenbach | - | 1. FSV Mainz 05 II | 1:1 | ||||
| 16. Round | 12/11/2022 | 1. FSV Mainz 05 II | - | FC-Astoria Walldorf | 1:2 | ||||
| 18. Round | 26/11/2022 | SSV Ulm 1846 | - | 1. FSV Mainz 05 II | 4:1 | ||||
| 19. Round | 03/12/2022 | 1. FSV Mainz 05 II | - | TSV Steinbach Haiger | 1:1 |
Germany