| 1. Round | 29/07/2021 | AD San Carlos | - | LD Alajuelense | 2:2 | ||||
| 3. Round | 08/08/2021 | LD Alajuelense | - | CS Cartaginés | 2:3 | ||||
| 4. Round | 12/08/2021 | Santos de Guápiles | - | LD Alajuelense | 2:1 | ||||
| 5. Round | 15/08/2021 | LD Alajuelense | - | CS Herediano | 4:1 | ||||
| 6. Round | 17/08/2021 | AD Guanacasteca | - | LD Alajuelense | 1:2 | ||||
| 7. Round | 26/08/2021 | LD Alajuelense | - | Municipal Grecia | 1:0 | ||||
| 9. Round | 08/09/2021 | LD Alajuelense | - | Jicaral | 2:0 | ||||
| 10. Round | 12/09/2021 | Guadalupe | - | LD Alajuelense | 2:4 | ||||
| 11. Round | 15/09/2021 | Municipal Pérez Zeledón | - | LD Alajuelense | 1:0 | ||||
| 12. Round | 18/09/2021 | LD Alajuelense | - | AD San Carlos | 2:2 | ||||
| 15. Round | 13/10/2021 | LD Alajuelense | - | Santos de Guápiles | 1:0 | ||||
| 22. Round | 28/11/2021 | LD Alajuelense | - | Municipal Pérez Zeledón | 3:0 |
Costa Rica