| 1. Round | 10/01/2021 | Deportivo Toluca [U20] | - | Gallos Blancos [U20] | 1:2 |  |
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| 2. Round | 16/01/2021 | Deportivo Guadalajara [U20] | - | Deportivo Toluca [U20] | 5:3 |  |
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| 3. Round | 24/01/2021 | Deportivo Toluca [U20] | - | Club Necaxa [U20] | 3:0 | |
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| 4. Round | 30/01/2021 | Club Tijuana [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 5. Round | 07/02/2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 6. Round | 14/02/2021 | Deportivo Toluca [U20] | - | Pumas UNAM [U20] | 2:2 | |
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| 7. Round | 20/02/2021 | Cruz Azul [U20] | - | Deportivo Toluca [U20] | 0:3 | |
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| 8. Round | 27/02/2021 | Deportivo Toluca [U20] | - | Atlas Guadalajara [U20] | 0:1 | |
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| 10. Round | 05/03/2021 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 11. Round | 14/03/2021 | Deportivo Toluca [U20] | - | CF Pachuca [U20] | 2:1 | |
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| 13. Round | 04/04/2021 | Club León [U20] | - | Deportivo Toluca [U20] | 0:4 |  |
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| 15. Round | 18/04/2021 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:2 | |
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Mexico