| 4. Round | 10/08/2021 | CF América [Women] | - | Deportivo Toluca [Women] | 1:3 |  |
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| 5. Round | 14/08/2021 | Deportivo Toluca [Women] | - | FC Juárez [Women] | 1:1 | ||||
| 6. Round | 24/08/2021 | CF Monterrey [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 10. Round | 28/09/2021 | Deportivo Toluca [Women] | - | Puebla FC [Women] | 1:1 | ||||
| 13. Round | 15/10/2021 | Gallos Blancos [Women] | - | Deportivo Toluca [Women] | 0:1 | ||||
| 14. Round | 30/10/2021 | Pumas UNAM [Women] | - | Deportivo Toluca [Women] | 2:0 | ||||
| 15. Round | 08/11/2021 | Deportivo Toluca [Women] | - | Club León [Women] | 0:3 | ||||
| 16. Round | 13/11/2021 | Mazatlán FC [Women] | - | Deportivo Toluca [Women] | 0:1 | ||||
| 17. Round | 19/11/2021 | Deportivo Toluca [Women] | - | Deportivo Guadalajara [Women] | 0:4 |
Mexico