| Group C | 13/04/2022 | Santos FC | - | Universidad Catolica | 3:2 |  |
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| Group C | 29/04/2022 | Unión La Calera | - | Santos FC | 1:1 | |
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| Group C | 06/05/2022 | Universidad Catolica | - | Santos FC | 0:1 | ||||
| Group C | 19/05/2022 | Santos FC | - | Unión La Calera | 1:0 | ||||
| Group C | 24/05/2022 | Santos FC | - | Banfield | 1:1 | ||||
| Round of 16 | 30/06/2022 | Deportivo Táchira | - | Santos FC | 1:1 | |
Ecuador