| 1. Round | 09/01/2022 | Cruz Azul | - | Club Tijuana | 2:0 | ||||
| 2. Round | 16/01/2022 | Cruz Azul | - | FC Juárez | 1:0 | ||||
| 3. Round | 23/01/2022 | CF Monterrey | - | Cruz Azul | 2:2 |  |
|||
| 4. Round | 08/02/2022 | Club León | - | Cruz Azul | 0:1 | ||||
| 5. Round | 13/02/2022 | Cruz Azul | - | Club Necaxa | 1:2 | ||||
| 6. Round | 21/02/2022 | Deportivo Toluca | - | Cruz Azul | 1:4 | ||||
| 7. Round | 28/02/2022 | Cruz Azul | - | Santos Laguna | 1:2 | ||||
| 8. Round | 03/03/2022 | UANL Tigres | - | Cruz Azul | 2:2 | ||||
| 9. Round | 06/03/2022 | Cruz Azul | - | Puebla FC | 1:3 | ||||
| 11. Round | 20/03/2022 | CF Pachuca | - | Cruz Azul | 1:0 |
Ecuador