| 2. Round | 15/01/2022 | Club Tijuana [U20] | - | Club León [U20] | 1:2 | ||||
| 3. Round | 22/01/2022 | Club León [U20] | - | CF Pachuca [U20] | 4:3 | ||||
| 4. Round | 07/02/2022 | Club León [U20] | - | Cruz Azul [U20] | 2:1 | ||||
| 5. Round | 13/02/2022 | Pumas UNAM [U20] | - | Club León [U20] | 2:1 | ||||
| 7. Round | 25/02/2022 | Club Necaxa [U20] | - | Club León [U20] | 0:3 | ||||
| 8. Round | 01/03/2022 | Club León [U20] | - | CF Monterrey [U20] | 1:2 | ||||
| 10. Round | 12/03/2022 | Club León [U20] | - | UANL Tigres [U20] | 2:1 |  |
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| 11. Round | 20/03/2022 | Mazatlán FC [U20] | - | Club León [U20] | 1:0 | ||||
| 12. Round | 03/04/2022 | Club León [U20] | - | Gallos Blancos [U20] | 2:1 | ||||
| 13. Round | 09/04/2022 | Atlético San Luis [U20] | - | Club León [U20] | 1:1 | ||||
| 14. Round | 16/04/2022 | Club León [U20] | - | Puebla FC [U20] | 4:1 | ||||
| 15. Round | 20/04/2022 | CF América [U20] | - | Club León [U20] | 2:1 |  |
USA
Mexico