| 1. Round | 10/01/2021 | CF América | - | Atlético San Luis | 2:1 | ||||
| 4. Round | 02/02/2021 | Club León | - | Atlético San Luis | 3:1 |  |
|||
| 5. Round | 05/02/2021 | Atlético San Luis | - | Club Tijuana | 2:2 | ||||
| 6. Round | 13/02/2021 | Mazatlán FC | - | Atlético San Luis | 0:3 | ||||
| 7. Round | 19/02/2021 | Atlético San Luis | - | Santos Laguna | 1:0 | ||||
| 8. Round | 26/02/2021 | Atlético San Luis | - | UANL Tigres | 2:2 | ||||
| 9. Round | 02/03/2021 | Atlas Guadalajara | - | Atlético San Luis | 3:1 | ||||
| 10. Round | 06/03/2021 | Atlético San Luis | - | Deportivo Toluca | 0:0 | ||||
| 11. Round | 15/03/2021 | Gallos Blancos | - | Atlético San Luis | 2:1 | ||||
| 12. Round | 20/03/2021 | Atlético San Luis | - | Pumas UNAM | 0:1 | ||||
| 13. Round | 04/04/2021 | CF Monterrey | - | Atlético San Luis | 2:0 | ||||
| 14. Round | 10/04/2021 | FC Juárez | - | Atlético San Luis | 2:1 | ||||
| 16. Round | 24/04/2021 | Cruz Azul | - | Atlético San Luis | 3:2 | ||||
| 17. Round | 30/04/2021 | Atlético San Luis | - | CF Pachuca | 1:5 |
Uruguay
Argentina