| 1. Round | 16/07/2022 | Sportivo Ameliano | - | Libertad | 2:0 | ||||
| 3. Round | 24/07/2022 | General Caballero DJLM | - | Libertad | 3:2 | ||||
| 10. Round | 10/09/2022 | Guaireña FC | - | Libertad | 4:0 | ||||
| 15. Round | 06/10/2022 | Resistencia SC | - | Libertad | 1:0 | ||||
| 19. Round | 27/10/2022 | Guaraní | - | Libertad | 1:2 | ||||
| 20. Round | 31/10/2022 | Libertad | - | Cerro Porteño | 0:0 | ||||
| 22. Round | 12/11/2022 | Tacuary | - | Libertad | 1:0 |  |
Uruguay
Argentina