| 3. Round | 23/01/2022 | Santos Laguna [U18] | - | Club Necaxa [U18] | 1:2 |  |
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| 4. Round | 05/02/2022 | Club Necaxa [U18] | - | CF Pachuca [U18] | 0:1 | ||||
| 5. Round | 12/02/2022 | Cruz Azul [U18] | - | Club Necaxa [U18] | 2:1 | ||||
| 6. Round | 18/02/2022 | Club Tijuana [U18] | - | Club Necaxa [U18] | 3:2 | |
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| 9. Round | 04/03/2022 | Club Necaxa [U18] | - | Deportivo Toluca [U18] | 0:1 | ||||
| 11. Round | 19/03/2022 | Pumas UNAM [U18] | - | Club Necaxa [U18] | 0:0 | ||||
| 1. Round | 25/03/2022 | FC Juárez [U18] | - | Club Necaxa [U18] | 5:3 | ||||
| 12. Round | 02/04/2022 | Club Necaxa [U18] | - | CF América [U18] | 2:2 | |
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| 13. Round | 07/04/2022 | Atlas Guadalajara [U18] | - | Club Necaxa [U18] | 1:3 | |
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| 14. Round | 15/04/2022 | Club Necaxa [U18] | - | Atlético San Luis [U18] | 1:2 | |
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| 16. Round | 22/04/2022 | Puebla FC [U18] | - | Club Necaxa [U18] | 1:4 | ||||
| 17. Round | 29/04/2022 | Club Necaxa [U18] | - | Deportivo Guadalajara [U18] | 1:3 |
Mexico