| 1. Round | 04/06/2022 | River Plate II | - | Defensa y Justicia II | 2:0 | ||||
| 2. Round | 09/06/2022 | Atlético Tucumán II | - | River Plate II | 1:0 | ||||
| 4. Round | 18/06/2022 | River Plate II | - | Unión de Santa Fe II | 2:0 | ||||
| 5. Round | 24/06/2022 | Lanús II | - | River Plate II | 1:5 | ||||
| 6. Round | 02/07/2022 | River Plate II | - | Huracán II | 1:0 | ||||
| 7. Round | 09/07/2022 | Godoy Cruz II | - | River Plate II | 0:1 | ||||
| 8. Round | 16/07/2022 | River Plate II | - | Vélez Sarsfield II | 0:2 | ||||
| 9. Round | 20/07/2022 | Gimnasia de La Plata II | - | River Plate II | 1:3 | ||||
| 10. Round | 25/07/2022 | River Plate II | - | Aldosivi II | 2:0 | ||||
| 11. Round | 30/07/2022 | Sarmiento de Junín II | - | River Plate II | 0:1 | ||||
| 12. Round | 06/08/2022 | River Plate II | - | Independiente II | 2:1 | ||||
| 13. Round | 11/08/2022 | Newell's Old Boys II | - | River Plate II | 2:0 | ||||
| 25. Round | 12/10/2022 | Platense II | - | River Plate II | 0:1 | ||||
| 26. Round | 16/10/2022 | Rosario Central II | - | River Plate II | 3:3 | ||||
| 27. Round | 20/10/2022 | River Plate II | - | Racing Club II | 1:2 |
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