| 1. Round | 03/07/2022 | UANL Tigres | - | Cruz Azul | 2:3 | ||||
| 2. Round | 10/07/2022 | Cruz Azul | - | CF Pachuca | 1:2 | ||||
| 3. Round | 16/07/2022 | Atlas Guadalajara | - | Cruz Azul | 3:2 | ||||
| 4. Round | 24/07/2022 | Cruz Azul | - | Puebla FC | 2:2 | ||||
| 5. Round | 27/07/2022 | Atlético San Luis | - | Cruz Azul | 0:0 |  |
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| 6. Round | 30/07/2022 | Cruz Azul | - | Club Necaxa | 1:0 | ||||
| 7. Round | 07/08/2022 | Santos Laguna | - | Cruz Azul | 4:0 | ||||
| 8. Round | 14/08/2022 | Cruz Azul | - | Deportivo Toluca | 2:3 | |
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| 9. Round | 18/08/2022 | Cruz Azul | - | Club Tijuana | 1:2 | ||||
| 10. Round | 21/08/2022 | CF América | - | Cruz Azul | 7:0 | ||||
| 11. Round | 27/08/2022 | Cruz Azul | - | Gallos Blancos | 2:1 | ||||
| 13. Round | 07/09/2022 | CF Monterrey | - | Cruz Azul | 3:2 |  |
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| 14. Round | 11/09/2022 | Cruz Azul | - | Mazatlán FC | 2:0 | ||||
| 16. Round | 16/09/2022 | Cruz Azul | - | Club León | 2:1 | ||||
| 15. Round | 18/09/2022 | Pumas UNAM | - | Cruz Azul | 1:2 | ||||
| 17. Round | 02/10/2022 | Cruz Azul | - | Deportivo Guadalajara | 2:1 | |
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Mexico