| 2. Round | 21/07/2022 | Club Nacional | - | Resistencia SC | 1:1 | ||||
| 4. Round | 30/07/2022 | Club Nacional | - | Sol de América | 3:0 | ||||
| 5. Round | 07/08/2022 | Cerro Porteño | - | Club Nacional | 0:0 | ||||
| 6. Round | 14/08/2022 | Guaraní | - | Club Nacional | 1:1 |  |
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| 7. Round | 21/08/2022 | Club Nacional | - | Libertad | 0:2 | ||||
| 8. Round | 26/08/2022 | Guaireña FC | - | Club Nacional | 1:3 | ||||
| 9. Round | 03/09/2022 | Club Nacional | - | Tacuary | 1:0 | ||||
| 10. Round | 11/09/2022 | Sportivo Ameliano | - | Club Nacional | 1:2 | ||||
| 11. Round | 16/09/2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
| 12. Round | 19/09/2022 | Club Nacional | - | General Caballero DJLM | 1:0 | ||||
| 14. Round | 03/10/2022 | Club Nacional | - | 12 de Octubre de Itauguá | 1:0 | ||||
| 15. Round | 06/10/2022 | Sol de América | - | Club Nacional | 2:3 | ||||
| 17. Round | 17/10/2022 | Club Nacional | - | Guaraní | 2:0 | ||||
| 19. Round | 27/10/2022 | Club Nacional | - | Guaireña FC | 3:0 | ||||
| 20. Round | 31/10/2022 | Tacuary | - | Club Nacional | 2:1 |  |
Paraguay