| 2. Round | 28/08/2021 | FC Meyrin | - | FC Echallens | 6:2 |  |
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| 4. Round | 11/09/2021 | FC Meyrin | - | US Terre Sainte | 1:0 | ||||
| 5. Round | 22/09/2021 | FC Bulle | - | FC Meyrin | 1:0 | ||||
| 7. Round | 02/10/2021 | FC Martigny Sports | - | FC Meyrin | 2:6 | ||||
| 8. Round | 16/10/2021 | FC Meyrin | - | FC Monthey | 1:2 | ||||
| 9. Round | 23/10/2021 | FC La Chaux-de-Fonds | - | FC Meyrin | 1:2 | ||||
| 10. Round | 30/10/2021 | FC Meyrin | - | Team Vaud Lausanne [U21] | 0:0 | ||||
| 11. Round | 07/11/2021 | FC Naters | - | FC Meyrin | 0:0 | ||||
| 12. Round | 13/11/2021 | FC Meyrin | - | FC Thun Berner Oberland II | 2:3 | ||||
| 13. Round | 20/11/2021 | Lancy FC | - | FC Meyrin | 1:2 |  |
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| 14. Round | 27/11/2021 | FC Meyrin | - | FC La Sarraz-Eclépens | 7:1 | ||||
| 15. Round | 05/03/2022 | FC Echallens | - | FC Meyrin | 3:0 dec. | ||||
| 19. Round | 02/04/2022 | Vevey-Sports | - | FC Meyrin | 3:1 | ||||
| 20. Round | 09/04/2022 | FC Meyrin | - | FC Martigny Sports | 0:2 | ||||
| 21. Round | 23/04/2022 | FC Monthey | - | FC Meyrin | 1:1 | ||||
| 23. Round | 08/05/2022 | Team Vaud Lausanne [U21] | - | FC Meyrin | 1:1 | ||||
| 26. Round | 28/05/2022 | FC Meyrin | - | Lancy FC | 1:1 |
Portugal