1. Round | 16/07/2022 | Tacuary | - | Guaireña FC | 0:0 | ||||
2. Round | 19/07/2022 | Guaireña FC | - | Sportivo Ameliano | 3:1 | ||||
4. Round | 29/07/2022 | Guaireña FC | - | General Caballero DJLM | 1:2 | ||||
8. Round | 26/08/2022 | Guaireña FC | - | Club Nacional | 1:3 | ||||
9. Round | 02/09/2022 | Guaraní | - | Guaireña FC | 2:2 | ||||
11. Round | 15/09/2022 | Cerro Porteño | - | Guaireña FC | 2:2 | ||||
12. Round | 18/09/2022 | Guaireña FC | - | Tacuary | 1:0 | ||||
13. Round | 23/09/2022 | Sportivo Ameliano | - | Guaireña FC | 2:0 | ||||
15. Round | 05/10/2022 | General Caballero DJLM | - | Guaireña FC | 0:0 | ||||
16. Round | 10/10/2022 | Guaireña FC | - | Resistencia SC | 3:2 | ||||
18. Round | 21/10/2022 | Guaireña FC | - | Sol de América | 0:0 | ||||
19. Round | 27/10/2022 | Club Nacional | - | Guaireña FC | 3:0 | ||||
21. Round | 06/11/2022 | Libertad | - | Guaireña FC | 4:2 | ||||
22. Round | 12/11/2022 | Guaireña FC | - | Cerro Porteño | 1:3 |