| Group 5 | 16/02/2000 | Cerro Porteño | - | Atlético Junior | 1:0 |  |
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| Group 5 | 01/03/2000 | Universitario de Deportes | - | Cerro Porteño | 1:0 | ||||
| Group 5 | 06/03/2000 | San Lorenzo | - | Cerro Porteño | 2:2 | ||||
| Group 5 | 14/03/2000 | Atlético Junior | - | Cerro Porteño | 2:0 | ||||
| Group 5 | 20/03/2000 | Cerro Porteño | - | Universitario de Deportes | 3:0 | ||||
| Group 5 | 05/04/2000 | Cerro Porteño | - | San Lorenzo | 3:1 | |
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| Round of 16 | 03/05/2000 | Cerro Porteño | - | River Plate | 0:4 | ||||
| Round of 16 | 09/05/2000 | River Plate | - | Cerro Porteño | 1:0 |  |
Paraguay
Ecuador