| 2. Round | 31/07/2021 | Club León [U18] | - | Club Tijuana [U18] | 2:1 | ||||
| 3. Round | 06/08/2021 | Club Tijuana [U18] | - | Deportivo Toluca [U18] | 3:0 | ||||
| 5. Round | 17/08/2021 | Club Tijuana [U18] | - | Puebla FC [U18] | 5:2 | ||||
| 6. Round | 22/08/2021 | CF América [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 8. Round | 10/09/2021 | Club Tijuana [U18] | - | Santos Laguna [U18] | 3:0 | ||||
| 9. Round | 16/09/2021 | Atlético San Luis [U18] | - | Club Tijuana [U18] | 1:0 | ||||
| 10. Round | 24/09/2021 | Club Tijuana [U18] | - | Mazatlán FC [U18] | 1:2 | ||||
| 14. Round | 20/10/2021 | Club Tijuana [U18] | - | Deportivo Guadalajara [U18] | 1:3 | ||||
| 17. Round | 10/11/2021 | Club Tijuana [U18] | - | CF Pachuca [U18] | 2:2 |
Mexico