| 2. Round | 31/07/2021 | Club León [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 3. Round | 05/08/2021 | Gallos Blancos [U20] | - | Club León [U20] | 1:0 | ||||
| 4. Round | 14/08/2021 | Club León [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 5. Round | 18/08/2021 | Deportivo Guadalajara [U20] | - | Club León [U20] | 1:2 | ||||
| 7. Round | 28/08/2021 | Club León [U20] | - | CF América [U20] | 2:2 | ||||
| 8. Round | 11/09/2021 | UANL Tigres [U20] | - | Club León [U20] | 2:0 | ||||
| 9. Round | 18/09/2021 | Club León [U20] | - | FC Juárez [U20] | 2:0 | ||||
| 10. Round | 25/09/2021 | Atlas Guadalajara [U20] | - | Club León [U20] | 2:1 | ||||
| 13. Round | 16/10/2021 | CF Monterrey [U20] | - | Club León [U20] | 1:1 | ||||
| 14. Round | 20/10/2021 | Club León [U20] | - | Pumas UNAM [U20] | 0:2 | ||||
| 16. Round | 31/10/2021 | Deportivo Toluca [U20] | - | Club León [U20] | 1:0 | ||||
| 11. Round | 03/11/2021 | Cruz Azul [U20] | - | Club León [U20] | 2:0 |
Mexico