| 1. Round | 08/01/2021 | Mazatlán FC [U20] | - | Club Necaxa [U20] | 2:0 |  |
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| 4. Round | 29/01/2021 | Mazatlán FC [U20] | - | CF Pachuca [U20] | 1:3 | ||||
| 5. Round | 07/02/2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 8. Round | 26/02/2021 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 3:1 | ||||
| 9. Round | 03/03/2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 2:2 | ||||
| 10. Round | 06/03/2021 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 2:1 | ||||
| 11. Round | 13/03/2021 | UANL Tigres [U20] | - | Mazatlán FC [U20] | 2:1 | ||||
| 12. Round | 19/03/2021 | Mazatlán FC [U20] | - | CF América [U20] | 1:0 | ||||
| 13. Round | 02/04/2021 | Puebla FC [U20] | - | Mazatlán FC [U20] | 6:2 | ||||
| 14. Round | 11/04/2021 | Club Tijuana [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 15. Round | 16/04/2021 | Mazatlán FC [U20] | - | Atlas Guadalajara [U20] | 2:2 | ||||
| 16. Round | 23/04/2021 | Mazatlán FC [U20] | - | Club León [U20] | 1:3 | ||||
| 17. Round | 01/05/2021 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 2:0 |
Mexico