| 1. Round | 09/01/2022 | CF Monterrey | - | Gallos Blancos | 0:0 | ||||
| 2. Round | 15/01/2022 | Club Necaxa | - | CF Monterrey | 0:4 | ||||
| 3. Round | 23/01/2022 | CF Monterrey | - | Cruz Azul | 2:2 | ||||
| 6. Round | 19/02/2022 | Puebla FC | - | CF Monterrey | 1:0 | ||||
| 7. Round | 26/02/2022 | CF Monterrey | - | Atlético San Luis | 0:2 | ||||
| 8. Round | 02/03/2022 | Club León | - | CF Monterrey | 0:0 | ||||
| 9. Round | 06/03/2022 | CF Monterrey | - | CF América | 2:1 |  |
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| 10. Round | 12/03/2022 | CF Monterrey | - | Mazatlán FC | 2:1 | ||||
| 5. Round | 16/03/2022 | CF Monterrey | - | FC Juárez | 3:0 | ||||
| 11. Round | 20/03/2022 | UANL Tigres | - | CF Monterrey | 2:0 | ||||
| 4. Round | 07/04/2022 | Deportivo Toluca | - | CF Monterrey | 2:2 | ||||
| 13. Round | 10/04/2022 | CF Monterrey | - | Santos Laguna | 1:0 | |
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| 12. Round | 14/04/2022 | Deportivo Guadalajara | - | CF Monterrey | 1:3 | ||||
| 15. Round | 21/04/2022 | CF Monterrey | - | Atlas Guadalajara | 0:0 |  |
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| 17. Round | 01/05/2022 | CF Monterrey | - | Club Tijuana | 2:0 |
Paraguay