| 1. Round | 04/07/2022 | Santos Laguna | - | CF Monterrey | 4:3 | ||||
| 2. Round | 10/07/2022 | CF Monterrey | - | CF América | 3:2 | ||||
| 3. Round | 17/07/2022 | Atlético San Luis | - | CF Monterrey | 0:1 | ||||
| 4. Round | 22/07/2022 | Gallos Blancos | - | CF Monterrey | 0:3 | ||||
| 5. Round | 27/07/2022 | CF Monterrey | - | Puebla FC | 1:0 | ||||
| 6. Round | 31/07/2022 | Pumas UNAM | - | CF Monterrey | 1:1 | ||||
| 7. Round | 07/08/2022 | CF Monterrey | - | Club León | 5:1 | ||||
| 8. Round | 13/08/2022 | Club Necaxa | - | CF Monterrey | 1:2 |  |
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| 9. Round | 18/08/2022 | Deportivo Toluca | - | CF Monterrey | 1:1 | ||||
| 10. Round | 21/08/2022 | CF Monterrey | - | UANL Tigres | 0:0 | ||||
| 12. Round | 04/09/2022 | CF Monterrey | - | Mazatlán FC | 0:0 | ||||
| 13. Round | 07/09/2022 | CF Monterrey | - | Cruz Azul | 3:2 | ||||
| 14. Round | 10/09/2022 | FC Juárez | - | CF Monterrey | 0:1 | ||||
| 15. Round | 18/09/2022 | CF Monterrey | - | Atlas Guadalajara | 2:0 | ||||
| 17. Round | 01/10/2022 | CF Monterrey | - | CF Pachuca | 0:0 |
Paraguay