| 1. Round | 26/07/2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 1:1 | ||||
| 3. Round | 06/08/2021 | Mazatlán FC [U20] | - | CF Monterrey [U20] | 1:4 | ||||
| 4. Round | 14/08/2021 | Club León [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 5. Round | 17/08/2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 |  |
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| 6. Round | 20/08/2021 | Mazatlán FC [U20] | - | UANL Tigres [U20] | 3:2 | ||||
| 7. Round | 27/08/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 3:1 | ||||
| 15. Round | 22/10/2021 | Mazatlán FC [U20] | - | Gallos Blancos [U20] | 4:0 | ||||
| 17. Round | 05/11/2021 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 1:0 |
Mexico