| 1. Round | 18/09/2021 | Leones Negros II | - | Gavilanes de Matamoros | 2:2 | ||||
| 2. Round | 25/09/2021 | Mazorqueros | - | Leones Negros II | 3:0 |  |
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| 3. Round | 02/10/2021 | Leones Negros II | - | Tecos Fútbol Club | 0:0 | ||||
| 4. Round | 10/10/2021 | Colima FC | - | Leones Negros II | 2:1 | |
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| 5. Round | 13/10/2021 | Correcaminos UAT II | - | Leones Negros II | 1:1 |
Mexico