| 1. Round | 16/02/2018 | Defensa y Justicia | - | América de Cali | 0:1 | ||||
| 1. Round | 09/03/2018 | América de Cali | - | Defensa y Justicia | 0:3 | ||||
| 2. Round | 18/07/2018 | Defensa y Justicia | - | El Nacional | 2:0 |  |
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| 2. Round | 31/07/2018 | El Nacional | - | Defensa y Justicia | 1:0 | ||||
| Round of 16 | 21/08/2018 | Defensa y Justicia | - | Banfield | 0:0 | ||||
| Round of 16 | 28/09/2018 | Banfield | - | Defensa y Justicia | 0:2 | ||||
| Quarter-finals | 26/10/2018 | Atlético Junior | - | Defensa y Justicia | 2:0 |
Uruguay